Guard Column cartridge, Bidentate C8 2.o, replacement, 2.0 mm ID x 10 mm long cartridge packed with 2.2 um, 120 A phase. Cogent TYPE-C Brand. 1 EA.
Additional Info:
The 40208‑PG3 Cogent Bidentate C8 2.0 Guard Column Cartridge is a single replacement cartridge designed for UHPLC and high‑pressure analytical systems, providing essential protection against particulates, contaminants, and strongly retained compounds.
Each cartridge is:
2.0 mm ID × 10 mm length
Packed with 2.2 µm, 120 Å TYPE‑C™ silica hydride Bidentate C8 2.0 phase
Constructed in stainless steel housing with SS frits
The cartridge is individually packaged in a protective Delrin™ case, preventing drying, contamination, or physical damage prior to installation.
⚠️ Requires guard column holder (sold separately)
Designed for 2.1 mm UHPLC Columns
This cartridge is optimized for:
2.1 mm ID analytical and UHPLC columns
Sub‑2 µm particle methods
LC‑MS and high‑sensitivity workflows
Proper guard matching ensures:
Minimal band broadening despite small particle size
Maintained high efficiency and resolution
Consistent retention and reproducibility
Why Use a Single Guard Cartridge
A single‑cartridge configuration is ideal when:
Testing different guard phases during method development
Using multiple analytical column chemistries
Replacing cartridges individually as needed
Maintaining flexibility without committing to multi‑packs
This provides maximum flexibility for precision workflows and optimization.
Why Use UHPLC Guard Column Protection
UHPLC columns using 2.2 µm particles are highly sensitive to:
Particulate contamination
Strongly retained or irreversible compounds
Matrix buildup from injected samples
Pressure increases due to blockage
The 40208‑PG3 cartridge acts as a critical sacrificial layer, helping to:
Preserve UHPLC column efficiency and resolution
Prevent rapid pressure buildup
Extend column lifetime
Maintain consistent analytical performance
Cartridges can be replaced quickly without disturbing the analytical column setup.
Bidentate C8 2.0™ Guard Phase Advantages
Using the same phase as your analytical column ensures:
Matched retention and selectivity behavior
Seamless analyte transfer
No need for method adjustment
Compared to C18 phases, Bidentate C8:
Reduces excessive hydrophobic retention
Improves recovery of amine‑containing compounds
Provides alternative selectivity for complex matrices
Supports fast equilibration in gradient methods
Cogent TYPE‑C™ Technology Benefits
Silica Hydride Surface
Reduced silanol activity
Improved peak shape for basic analytes
Lower secondary interactions
High‑Pressure Stability
Designed for UHPLC / sub‑2 µm workflows
Performs reliably under elevated pressures
Maintains performance over extended use
Faster Equilibration
Reduced cycle times
Improved throughput for high‑efficiency methods
Typical Applications
UHPLC and LC‑MS analytical methods
Pharmaceutical and bioanalytical workflows
High‑resolution separations
Complex sample matrices
Methods using sub‑2 µm Bidentate C8 columns